Gene-environment interactions play a pivotal role in shaping an individuals susceptibility to infectious diseases. The intricate interplay between genetic predispositions and external factors can significantly influence the likelihood of disease development and progression. Understanding how genes and the environment interact in the context of infectious diseases is crucial for advancing preventive and therapeutic strategies. This article delves into the impact of gene-environment interactions on disease susceptibility, exploring the mechanisms, implications for public health, and avenues for future research in this critical field.