Aging is a natural biological process characterized by a progressive decline in physiological function and cellular integrity over time. With aging comes the phenomenon of senescence, a state of irreversible growth arrest that limits the replicative capacity of cells. Understanding the intricate interplay between aging and senescence is crucial in unraveling the mechanisms underlying age-related diseases and longevity. This article delves into the role of aging and senescence in shaping health outcomes, exploring the impact on age-related diseases and strategies for promoting healthy aging and longevity.